I used to do a 70% waterchange on our 6 x 2 x 2.5 tank which held 1 ton of water or 220 gallons imperial diesilplower 80% is pushing it a tad what size tanks are we on about ?I do 80% water changes in my aquariums every few weeks and it does not negatively impact my fish. I wonder if you have had a large PH swing? Are the fish handing out near the filter return where the water may have more oxygen?
But thats each to there own if it works for you however you may well be on to something here if the answer is yes most probably parasitic
Dave